Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective cure. 3CL protease (3CL(pro)) is a highly conserved cysteine proteinase that is indispensable for coronavirus replication, providing an attra...

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Detalles Bibliográficos
Autores principales: Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206078/
https://www.ncbi.nlm.nih.gov/pubmed/34131140
http://dx.doi.org/10.1038/s41467-021-23751-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206078/
https://www.ncbi.nlm.nih.gov/pubmed/34131140
http://dx.doi.org/10.1038/s41467-021-23751-3

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