Glucocorticoid resistance conferring mutation in the C-terminus of GR alters the receptor conformational dynamics

The glucocorticoid receptor is a key regulator of essential physiological processes, which under the control of the Hsp90 chaperone machinery, binds to steroid hormones and steroid-like molecules and in a rather complicated and elusive response, regulates a set of glucocorticoid responsive genes. We...

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Detalles Bibliográficos
Autores principales: Kaziales, Anna, Rührnößl, Florian, Richter, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206104/
https://www.ncbi.nlm.nih.gov/pubmed/34131228
http://dx.doi.org/10.1038/s41598-021-92039-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206104/
https://www.ncbi.nlm.nih.gov/pubmed/34131228
http://dx.doi.org/10.1038/s41598-021-92039-9

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