Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses

PPM1D/Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human solid tumors. Recent reports associate gain-of-function mutations of PPM1D in immune cells with worse outcomes for several human cancers. Here we show that mice with genetic knockout of Ppm1d or with...

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Detalles Bibliográficos
Autores principales: Uyanik, Burhan, Goloudina, Anastasia R., Akbarali, Aamir, Grigorash, Bogdan B., Petukhov, Alexey V., Singhal, Sunil, Eruslanov, Evgeniy, Chaloyard, Jeanne, Lagorgette, Lisa, Hadi, Tarik, Baidyuk, Ekaterina V., Sakai, Hiroyasu, Tessarollo, Lino, Ryffel, Bernhard, Mazur, Sharlyn J., Lirussi, Frederic, Garrido, Carmen, Appella, Ettore, Demidov, Oleg N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206133/
https://www.ncbi.nlm.nih.gov/pubmed/34131120
http://dx.doi.org/10.1038/s41467-021-23330-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206133/
https://www.ncbi.nlm.nih.gov/pubmed/34131120
http://dx.doi.org/10.1038/s41467-021-23330-6

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