iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

Here, we identify iPLA2β as a critical regulator for p53-driven ferroptosis upon reactive oxygen species (ROS)-induced stress. The calcium-independent phospholipase iPLA2β is known to cleave acyl tails from the glycerol backbone of lipids and release oxidized fatty acids from phospholipids. We found...

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Detalles Bibliográficos
Autores principales: Chen, Delin, Chu, Bo, Yang, Xin, Liu, Zhaoqi, Jin, Ying, Kon, Ning, Rabadan, Raul, Jiang, Xuejun, Stockwell, Brent R., Gu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206155/
https://www.ncbi.nlm.nih.gov/pubmed/34131139
http://dx.doi.org/10.1038/s41467-021-23902-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206155/
https://www.ncbi.nlm.nih.gov/pubmed/34131139
http://dx.doi.org/10.1038/s41467-021-23902-6

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