Cargando…

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

Here, we identify iPLA2β as a critical regulator for p53-driven ferroptosis upon reactive oxygen species (ROS)-induced stress. The calcium-independent phospholipase iPLA2β is known to cleave acyl tails from the glycerol backbone of lipids and release oxidized fatty acids from phospholipids. We found...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Delin, Chu, Bo, Yang, Xin, Liu, Zhaoqi, Jin, Ying, Kon, Ning, Rabadan, Raul, Jiang, Xuejun, Stockwell, Brent R., Gu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206155/ https://www.ncbi.nlm.nih.gov/pubmed/34131139 http://dx.doi.org/10.1038/s41467-021-23902-6

Ejemplares similares

Phospholipase iPLA2β acts as a guardian against ferroptosis
por: Mao, Chao, et al.
Publicado: (2021)

Phospholipase iPLA(2)β Averts Ferroptosis By Eliminating A Redox Lipid Death Signal
por: Sun, Wan-Yang, et al.
Publicado: (2021)

p21 can be a barrier to ferroptosis independent of p53
por: Venkatesh, Divya, et al.
Publicado: (2020)

The Impact of the Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) on Immune Cells
por: White, Tayleur D., et al.
Publicado: (2021)

iPLA(2)β: front and center in human monocyte chemotaxis to MCP-1
por: Mishra, Ravi S., et al.
Publicado: (2008)

Long-Term Lithium Treatment Increases cPLA(2) and iPLA(2) Activity in Cultured Cortical and Hippocampal Neurons
por: De-Paula, Vanessa de Jesus, et al.
Publicado: (2015)

The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity
por: Gentry, Clive, et al.
Publicado: (2010)

Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development
por: Yun, H-M, et al.
Publicado: (2014)

Group VIB Calcium-Independent Phospholipase A(2) (iPLA(2)γ) Regulates Platelet Activation, Hemostasis and Thrombosis in Mice
por: Yoda, Emiko, et al.
Publicado: (2014)

GPX4-independent ferroptosis—a new strategy in disease’s therapy
por: Ma, Tianyu, et al.
Publicado: (2022)

The structure of iPLA(2)β reveals dimeric active sites and suggests mechanisms of regulation and localization
por: Malley, Konstantin R., et al.
Publicado: (2018)

iPLA(2)-VIA is required for healthy aging of neurons, muscle, and the female germline in Drosophila melanogaster
por: Banerjee, Surya Jyoti, et al.
Publicado: (2021)

Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
por: Bone, Robert N., et al.
Publicado: (2015)

iPLA(2)β Overexpression in Smooth Muscle Exacerbates Angiotensin II-Induced Hypertension and Vascular Remodeling
por: Calderon, Lindsay E., et al.
Publicado: (2012)

High-fat diet activates liver iPLA(2)γ generating eicosanoids that mediate metabolic stress
por: Moon, Sung Ho, et al.
Publicado: (2021)

iPLA(2)β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury
por: Jin, Tingting, et al.
Publicado: (2021)

FINO(2) Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation
por: Gaschler, Michael M., et al.
Publicado: (2018)

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling
por: Mori, Akio, et al.
Publicado: (2019)

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma
por: Banu, Matei A., et al.
Publicado: (2023)

Berberine Inhibits the Apoptosis-Induced Metastasis by Suppressing the iPLA2/LOX-5/LTB4 Pathway in Hepatocellular Carcinoma
por: Zhao, Yawei, et al.
Publicado: (2020)

iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment
por: Andrade, Adriana, et al.
Publicado: (2022)

xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers
por: Lee, Namgyu, et al.
Publicado: (2021)

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
por: Feng, Huizhong, et al.
Publicado: (2018)

Deficiency of iPLA(2)β Primes Immune Cells for Proinflammation: Potential Involvement in Age-Related Mesenteric Lymph Node Lymphoma
por: Inhoffen, Johannes, et al.
Publicado: (2015)

Rescue of Hepatic Phospholipid Remodeling Defect in iPLA(2)β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver
por: Chamulitrat, Walee, et al.
Publicado: (2020)

Characterization of FKGK18 as Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A(2) (iPLA(2)β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes
por: Ali, Tomader, et al.
Publicado: (2013)

Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition
por: Yi, Renxin, et al.
Publicado: (2020)

Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
por: Miao, Yu, et al.
Publicado: (2022)

Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis
por: Shimizu, Junji, et al.
Publicado: (2022)

Copper-dependent autophagic degradation of GPX4 drives ferroptosis
por: Xue, Qian, et al.
Publicado: (2023)

Genetic modulation of islet β-cell iPLA(2)β expression provides evidence for its impact on β-cell apoptosis and autophagy
por: Lei, Xiaoyong, et al.
Publicado: (2013)

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid–Conducting SLC25 Gene Family Transporters
por: Jabůrek, Martin, et al.
Publicado: (2021)

Genetic deletion of skeletal muscle iPLA(2)γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
por: Moon, Sung Ho, et al.
Publicado: (2023)

GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma
por: Zhou, Yan, et al.
Publicado: (2022)

ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease
por: Song, Shujuan, et al.
Publicado: (2023)

Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway
por: Wang, Xingjie, et al.
Publicado: (2023)

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
por: Agmon, Eran, et al.
Publicado: (2018)

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma
por: Wang, Zhixian, et al.
Publicado: (2021)

ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway
por: Chu, Bo, et al.
Publicado: (2019)

Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA(2)β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes
por: Ali, Tomader, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9d0j5l9fjdpe3u2qi1r47bkjhc