Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

The accuracy of polygenic risk scores (PRSs) to predict complex diseases increases with the training sample size. PRSs are generally derived based on summary statistics from large meta-analyses of multiple genome-wide association studies (GWASs). However, it is now common for researchers to have acc...

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Detalles Bibliográficos
Autores principales: Albiñana, Clara, Grove, Jakob, McGrath, John J., Agerbo, Esben, Wray, Naomi R., Bulik, Cynthia M., Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Børglum, Anders D., Mortensen, Preben Bo, Privé, Florian, Vilhjálmsson, Bjarni J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206385/
https://www.ncbi.nlm.nih.gov/pubmed/33964208
http://dx.doi.org/10.1016/j.ajhg.2021.04.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206385/
https://www.ncbi.nlm.nih.gov/pubmed/33964208
http://dx.doi.org/10.1016/j.ajhg.2021.04.014

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