Protein Predictive Modeling and Simulation of Mutations of Presenilin-1 Familial Alzheimer’s Disease on the Orthosteric Site

Alzheimer’s disease pathology is characterized by β-amyloid plaques and neurofibrillary tangles. Amyloid precursor protein is processed by β and γ secretase, resulting in the production of β-amyloid peptides with a length ranging from 38 to 43 amino acids. Presenilin 1 (PS1) is the catalytic unit of...

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Detalles Bibliográficos
Autores principales: Soto-Ospina, Alejandro, Araque Marín, Pedronel, Bedoya, Gabriel, Sepulveda-Falla, Diego, Villegas Lanau, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206637/
https://www.ncbi.nlm.nih.gov/pubmed/34150846
http://dx.doi.org/10.3389/fmolb.2021.649990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206637/
https://www.ncbi.nlm.nih.gov/pubmed/34150846
http://dx.doi.org/10.3389/fmolb.2021.649990

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