Stabilization of Hypoxia-Inducible Factor Promotes Antimicrobial Activity of Human Macrophages Against Mycobacterium tuberculosis

Hypoxia-inducible factor (HIF) is a key oxygen sensor that controls gene expression patterns to adapt cellular metabolism to hypoxia. Pharmacological inhibition of prolyl-hydroxylases stabilizes HIFs and mimics hypoxia, leading to increased expression of more than 300 genes. Whether the genetic prog...

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Detalles Bibliográficos
Autores principales: Zenk, Sebastian F., Hauck, Sebastian, Mayer, Daniel, Grieshober, Mark, Stenger, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206807/
https://www.ncbi.nlm.nih.gov/pubmed/34149713
http://dx.doi.org/10.3389/fimmu.2021.678354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206807/
https://www.ncbi.nlm.nih.gov/pubmed/34149713
http://dx.doi.org/10.3389/fimmu.2021.678354

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