Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

The sustained proliferation of microglia is a key hallmark of Alzheimer’s disease (AD), accelerating its progression. Here, we aim to understand the long-term impact of the early and prolonged microglial proliferation observed in AD, hypothesizing that extensive and repeated cycling would engender a...

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Detalles Bibliográficos
Autores principales: Hu, Yanling, Fryatt, Gemma L., Ghorbani, Mohammadmersad, Obst, Juliane, Menassa, David A., Martin-Estebane, Maria, Muntslag, Tim A.O., Olmos-Alonso, Adrian, Guerrero-Carrasco, Monica, Thomas, Daniel, Cragg, Mark S., Gomez-Nicola, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206957/
https://www.ncbi.nlm.nih.gov/pubmed/34107254
http://dx.doi.org/10.1016/j.celrep.2021.109228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206957/
https://www.ncbi.nlm.nih.gov/pubmed/34107254
http://dx.doi.org/10.1016/j.celrep.2021.109228

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