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Cytoplasmic‐translocated Ku70 senses intracellular DNA and mediates interferon‐lambda1 induction
We have previously identified that human Ku70, a nuclear protein, serves as a cytosolic DNA sensor. Upon transfection with DNA or infection with DNA virus, Ku70 translocates from the nucleus into the cytoplasm and then predominately induces interferon lambda1 (IFN‐λ1) rather than IFN‐alpha or IFN‐be...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207419/ https://www.ncbi.nlm.nih.gov/pubmed/33548066 http://dx.doi.org/10.1111/imm.13318 |