Highly Diastereoselective Construction of Carbon– Heteroatom Quaternary Stereogenic Centers in the Synthesis of Analogs of Bioactive Compounds: From Monofluorinated Epoxyalkylphosphonates to α-Fluoro-, β-, or γ-Amino Alcohol Derivatives of Alkylphosphonates

The synthesis of the stable surrogates of an important amino acid (R)-4-amino-3-hydroxybutyric acid (GABOB) such as substituted hydroxy aminophosphonic acids bearing a quaternary stereogenic center is presented. Highly diastereoselective formations of fluorinated spiroepoxy alkylphosphonate or relat...

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Detalles Bibliográficos
Autores principales: Rapp, Magdalena, Margas-Musielak, Klaudia, Kaczmarek, Patrycja, Witkowska, Agnieszka, Cytlak, Tomasz, Siodła, Tomasz, Koroniak, Henryk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208234/
https://www.ncbi.nlm.nih.gov/pubmed/34150715
http://dx.doi.org/10.3389/fchem.2021.613633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208234/
https://www.ncbi.nlm.nih.gov/pubmed/34150715
http://dx.doi.org/10.3389/fchem.2021.613633

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