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The Ras dimer structure
Oncogenic mutated Ras is a key player in cancer, but despite intense and expensive approaches its catalytic center seems undruggable. The Ras dimer interface is a possible alternative drug target. Dimerization at the membrane affects cell growth signal transduction. In vivo studies indicate that pre...
Autores principales: | Rudack, Till, Teuber, Christian, Scherlo, Marvin, Güldenhaupt, Jörn, Schartner, Jonas, Lübben, Mathias, Klare, Johann, Gerwert, Klaus, Kötting, Carsten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208300/ https://www.ncbi.nlm.nih.gov/pubmed/34194708 http://dx.doi.org/10.1039/d1sc00957e |
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