Cargando…

Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells

Clofarabine, an FDA approved purine analog, is used in the treatment of relapsed or refractory acute lymphoblastic leukemia. Clofarabine acts by inhibiting DNA synthesis. We demonstrated that clofarabine may have a novel function though inhibiting CD99, a transmembrane protein highly expressed on Ew...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sevim, Handan, Çelik, Haydar, Düşünceli, Levent, Ceyhan, Ceyda S., Molotkova, Anna, Nakazawa, Kay, Graham, Garrett T., Petro, Jeffrey R., Toretsky, Jeffrey A., Üren, Aykut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208565/ https://www.ncbi.nlm.nih.gov/pubmed/34133426 http://dx.doi.org/10.1371/journal.pone.0253170

Ejemplares similares

Insulin-Like Growth Factor 1 Receptor as a Therapeutic Target in Ewing Sarcoma: Lack of Consistent Upregulation or Recurrent Mutation and a Review of the Clinical Trial Literature
por: O'Neill, Alison, et al.
Publicado: (2013)

Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma
por: Graham, Garrett T, et al.
Publicado: (2022)

Synthesis and Structure–Activity Relationship Studies of Small Molecule Disruptors of EWS-FLI1 Interactions in Ewing’s Sarcoma
por: Tosso, Perrer N., et al.
Publicado: (2014)

Pharmacokinetic modeling optimizes inhibition of the ‘undruggable’ EWS-FLI1 transcription factor in Ewing Sarcoma
por: Hong, Sung-Hyeok, et al.
Publicado: (2013)

MSK1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating CREB
por: Li, Jianchang, et al.
Publicado: (2019)

Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non–Small Cell Lung Cancer Cells()
por: Saygideğer-Kont, Yasemin, et al.
Publicado: (2016)

Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model
por: Minas, Tsion Zewdu, et al.
Publicado: (2016)

Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA Helicase A inhibits Ewing's Sarcoma
por: Erkizan, Hayriye V., et al.
Publicado: (2009)

Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity
por: Nakazawa, Kay, et al.
Publicado: (2023)

YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion
por: Rahim, Said, et al.
Publicado: (2011)

Use of clofarabine for acute childhood leukemia
por: Pession, A, et al.
Publicado: (2010)

Dual anti-HIV mechanism of clofarabine
por: Daly, Michele B., et al.
Publicado: (2016)

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells
por: Bierbaumer, Lisa, et al.
Publicado: (2021)

A Small Molecule Inhibitor of ETV1, YK-4-279, Prevents Prostate Cancer Growth and Metastasis in a Mouse Xenograft Model
por: Rahim, Said, et al.
Publicado: (2014)

Treating refractory leukemias in childhood, role of clofarabine
por: Harned, Theresa M, et al.
Publicado: (2008)

Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2
por: Reyskens, Kathleen M. S. E., et al.
Publicado: (2016)

IL-33 induces granzyme C expression in murine mast cells via an MSK1/2-CREB-dependent pathway
por: Phair, Iain R., et al.
Publicado: (2022)

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model
por: Minas, Tsion Zewdu, et al.
Publicado: (2015)

Clofarabine Experience in Children with Multi-Relapsed Acute Leukemia
por: Karakaş, Zeynep, et al.
Publicado: (2014)

[(18)F] Clofarabine for PET Imaging of Hepatocellular Carcinoma
por: Sergeeva, Olga, et al.
Publicado: (2019)

Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity
por: Schlottmann, Silke, et al.
Publicado: (2012)

Editorial Seminars in MSK Radiology
por: Simoni, Paolo, et al.
Publicado: (2017)

MSK Ultrasound - An IJSPT Perspective
por: Page, Phil, et al.
Publicado: (2023)

MSK30: a validated tool to assess clinical musculoskeletal knowledge
por: Cummings, Danielle L, et al.
Publicado: (2019)

Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines
por: Valdez, B C, et al.
Publicado: (2014)

Clofarabine desensitization: A case report: Leukemia research reports
por: Hayes, Sarah M., et al.
Publicado: (2017)

Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters
por: Miller, Siennah R., et al.
Publicado: (2021)

Clofarabine monotherapy in two patients with refractory Langerhans cell histiocytosis
por: Irie, Masahiro, et al.
Publicado: (2021)

Patient-Level Meta-analysis of Clofarabine in Acute Lymphoblastic Leukemia
por: Jeha, Sima, et al.
Publicado: (2023)

The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory
por: Daumas, Stephanie, et al.
Publicado: (2017)

Sulforaphene induces apoptosis and inhibits the invasion of esophageal cancer cells through MSK2/CREB/Bcl-2 and cadherin pathway in vivo and in vitro
por: Zhang, Chengjuan, et al.
Publicado: (2019)

Iron distribution in different tissues of homozygous Mask (msk/msk) mice and the effects of oral iron treatments
por: Asperti, Michela, et al.
Publicado: (2021)

Older Adult Use and Outcomes in a Digital Musculoskeletal (MSK) Program, by Generation
por: Wang, Grace, et al.
Publicado: (2021)

Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers
por: Elcombe, Suzanne E., et al.
Publicado: (2013)

Efficacy of Low Dose Clofarabine in Refractory Precursor T- Acute Lymphoblastic Leukemia
por: Choi, Jaehyuk, et al.
Publicado: (2007)

A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer
por: Khalafi, Shayan, et al.
Publicado: (2021)

Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients
por: Nijstad, A. Laura, et al.
Publicado: (2021)

Renal Angiomyolipoma With Caval Extension and Pulmonary Fat Embolism: A Case Report
por: Celik, Suleyman Utku, et al.
Publicado: (2015)

AI MSK clinical applications: spine imaging
por: Huber, Florian A., et al.
Publicado: (2021)

The Use of MSK Ultrasound with Quadriceps Muscle Injury
por: Manske, Robert C, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ds6lgdf3a8ojum5i0lqv7ggd0a