Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents

Greater blood pressure (BP) is associated with greater left ventricular mass indexed to height(2.7) (LVMi(2.7)) in adolescents. This study examined whether greater BP variability and reduced night-time dipping are associated with cardiac remodeling in a general population of adolescents. A cross-sec...

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Autores principales: Goudswaard, Lucy J., Harrison, Sean, Van De Klee, Daniel, Chaturvedi, Nishi, Lawlor, Debbie A., Davey Smith, George, Hughes, Alun D., Howe, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208567/
https://www.ncbi.nlm.nih.gov/pubmed/34133455
http://dx.doi.org/10.1371/journal.pone.0253196
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author Goudswaard, Lucy J.
Harrison, Sean
Van De Klee, Daniel
Chaturvedi, Nishi
Lawlor, Debbie A.
Davey Smith, George
Hughes, Alun D.
Howe, Laura D.
author_facet Goudswaard, Lucy J.
Harrison, Sean
Van De Klee, Daniel
Chaturvedi, Nishi
Lawlor, Debbie A.
Davey Smith, George
Hughes, Alun D.
Howe, Laura D.
author_sort Goudswaard, Lucy J.
collection PubMed
description Greater blood pressure (BP) is associated with greater left ventricular mass indexed to height(2.7) (LVMi(2.7)) in adolescents. This study examined whether greater BP variability and reduced night-time dipping are associated with cardiac remodeling in a general population of adolescents. A cross-sectional analysis was undertaken in 587 UK adolescents (mean age 17.7 years; 43.1% male). BP was measured in a research clinic and using 24-hour ambulatory monitoring. We examined associations (for both systolic and diastolic BP) of: 1) clinic and 24-hour mean BP; 2) measures of 24-hour BP variability: standard deviation weighted for day/night (SDdn), variability independent of the mean (VIM) and average real variability (ARV); and 3) night-time dipping with cardiac structures. Cardiac structures were assessed by echocardiography: 1) LVMi(2.7); 2) relative wall thickness (RWT); 3) left atrial diameter indexed to height (LADi) and 4) left ventricular internal diameter in diastole (LVIDD). Higher systolic BP was associated with greater LVMi(2.7). Systolic and diastolic BP were associated with greater RWT. Associations were inconsistent for LADi and LVIDD. There was evidence for associations between both greater SDdn and ARV and higher RWT (per 1 SD higher diastolic ARV, mean difference in RWT was 0.13 SDs, 95% CI 0.045 to 0.21); these associations with RWT remained after adjustment for mean BP. There was no consistent evidence of associations between night-time dipping and cardiac structure. Measurement of BP variability, even in adolescents with blood pressure in the physiologic range, might benefit risk of cardiovascular remodeling assessment.
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spelling pubmed-82085672021-06-29 Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents Goudswaard, Lucy J. Harrison, Sean Van De Klee, Daniel Chaturvedi, Nishi Lawlor, Debbie A. Davey Smith, George Hughes, Alun D. Howe, Laura D. PLoS One Research Article Greater blood pressure (BP) is associated with greater left ventricular mass indexed to height(2.7) (LVMi(2.7)) in adolescents. This study examined whether greater BP variability and reduced night-time dipping are associated with cardiac remodeling in a general population of adolescents. A cross-sectional analysis was undertaken in 587 UK adolescents (mean age 17.7 years; 43.1% male). BP was measured in a research clinic and using 24-hour ambulatory monitoring. We examined associations (for both systolic and diastolic BP) of: 1) clinic and 24-hour mean BP; 2) measures of 24-hour BP variability: standard deviation weighted for day/night (SDdn), variability independent of the mean (VIM) and average real variability (ARV); and 3) night-time dipping with cardiac structures. Cardiac structures were assessed by echocardiography: 1) LVMi(2.7); 2) relative wall thickness (RWT); 3) left atrial diameter indexed to height (LADi) and 4) left ventricular internal diameter in diastole (LVIDD). Higher systolic BP was associated with greater LVMi(2.7). Systolic and diastolic BP were associated with greater RWT. Associations were inconsistent for LADi and LVIDD. There was evidence for associations between both greater SDdn and ARV and higher RWT (per 1 SD higher diastolic ARV, mean difference in RWT was 0.13 SDs, 95% CI 0.045 to 0.21); these associations with RWT remained after adjustment for mean BP. There was no consistent evidence of associations between night-time dipping and cardiac structure. Measurement of BP variability, even in adolescents with blood pressure in the physiologic range, might benefit risk of cardiovascular remodeling assessment. Public Library of Science 2021-06-16 /pmc/articles/PMC8208567/ /pubmed/34133455 http://dx.doi.org/10.1371/journal.pone.0253196 Text en © 2021 Goudswaard et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Goudswaard, Lucy J.
Harrison, Sean
Van De Klee, Daniel
Chaturvedi, Nishi
Lawlor, Debbie A.
Davey Smith, George
Hughes, Alun D.
Howe, Laura D.
Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents
title Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents
title_full Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents
title_fullStr Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents
title_full_unstemmed Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents
title_short Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents
title_sort blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: cross-sectional association with cardiac structure in adolescents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208567/
https://www.ncbi.nlm.nih.gov/pubmed/34133455
http://dx.doi.org/10.1371/journal.pone.0253196
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