m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity

N(6)-methyladenosine (m(6)A) modification is dynamically regulated by “writer” and “eraser” enzymes. m(6)A “writers” have been shown to ensure the homeostasis of CD4(+) T cells, but the “erasers” functioning in T cells is poorly understood. Here, we reported that m(6)A eraser AlkB homolog 5 (ALKBH5)...

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Detalles Bibliográficos
Autores principales: Zhou, Jing, Zhang, Xingli, Hu, Jiajia, Qu, Rihao, Yu, Zhibin, Xu, Hao, Chen, Huifang, Yan, Lichong, Ding, Chenbo, Zou, Qiang, Ye, Youqiong, Wang, Zhengting, Flavell, Richard A., Li, Hua-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208713/
https://www.ncbi.nlm.nih.gov/pubmed/34134995
http://dx.doi.org/10.1126/sciadv.abg0470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208713/
https://www.ncbi.nlm.nih.gov/pubmed/34134995
http://dx.doi.org/10.1126/sciadv.abg0470

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