Cargando…

Therapeutic efficacy of novel memantine nitrate MN‐08 in animal models of Alzheimer’s disease

Alzheimer's disease (AD) is a leading cause of dementia in elderly individuals and therapeutic options for AD are very limited. Over‐activation of N‐methyl‐D‐aspartate (NMDA) receptors, amyloid β (Aβ) aggregation, a decrease in cerebral blood flow (CBF), and downstream pathological events play...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Liangmiao, Zhou, Xinhua, Cao, Yiwan, MAK, Shing Hung, Zha, Ling, Li, Ning, Su, Zhiyang, Han, Yifan, Wang, Yuqiang, Man Hoi, Maggie Pui, Sun, Yewei, Zhang, Gaoxiao, Zhang, Zaijun, Yang, Xifei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208785/ https://www.ncbi.nlm.nih.gov/pubmed/33955647 http://dx.doi.org/10.1111/acel.13371

Ejemplares similares

Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease
por: Zhou, Xinhua, et al.
Publicado: (2019)

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis
por: Zhou, Xinhua, et al.
Publicado: (2023)

Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson’s disease models through activating the MEF2-PGC1α and BDNF/CREB pathways
por: Chen, Haiyun, et al.
Publicado: (2020)

Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease
por: Jing, Mei, et al.
Publicado: (2021)

Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury
por: Zhou, Xinhua, et al.
Publicado: (2015)

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways
por: Chen, Haiyun, et al.
Publicado: (2018)

Tetramethylpyrazine nitrone activates hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia
por: Cen, Yun, et al.
Publicado: (2022)

Murine Beta-Amyloid (1–42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors
por: Yue, Qian, et al.
Publicado: (2022)

Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways
por: Yang, Yali, et al.
Publicado: (2016)

Oxygen-Coordinated Single Mn Sites for Efficient Electrocatalytic Nitrate Reduction to Ammonia
por: Zhang, Shengbo, et al.
Publicado: (2023)

Corrigendum: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy
por: Cui, Guozhen, et al.
Publicado: (2015)

Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy
por: Cui, Guozhen, et al.
Publicado: (2015)

Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy
por: Zhang, Zaijun, et al.
Publicado: (2016)

Pharmacodynamics of Memantine: An Update
por: Rammes, G, et al.
Publicado: (2008)

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor
por: Hu, Shengquan, et al.
Publicado: (2018)

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2015)

The effects of memantine on prepulse inhibition
por: Swerdlow, NR, et al.
Publicado: (2009)

Pharmacokinetics of memantine in rats and mice
por: Beconi, Maria G., et al.
Publicado: (2012)

Memantine Ameliorates Migraine Headache
por: Shanmugam, Sundar, et al.
Publicado: (2019)

Improved electrical transport properties of polycrystalline La(0.8)(Ca(0.12)Sr(0.08))MnO(3) ceramics by Ag(2)O doping
por: Dong, Gang, et al.
Publicado: (2019)

A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer
por: Zhou, Xinhua, et al.
Publicado: (2019)

Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2016)

08.08.08, czyli najbardziej zagadkowy dzień roku
Publicado: (2008)

HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells
por: Zhang, Yanyan, et al.
Publicado: (2018)

Natural Dietary Compound Xanthohumol Regulates the Gut Microbiota and Its Metabolic Profile in a Mouse Model of Alzheimer’s Disease
por: Liu, Wei, et al.
Publicado: (2022)

Update on the use of memantine in Alzheimer’s disease
por: van Marum, Robert J
Publicado: (2009)

Memantine as an Augmentation Therapy for Anxiety Disorders
por: Schwartz, Thomas L., et al.
Publicado: (2012)

Tackling Negative Symptoms of Schizophrenia with Memantine
por: Paraschakis, Antonios
Publicado: (2014)

Efficacy of Memantine Hydrochloride in Neuropathic Pain
por: Nair, Abhijit S, et al.
Publicado: (2019)

Memantine in neurological disorders – schizophrenia and depression
por: Czarnecka, Kamila, et al.
Publicado: (2021)

Pharmacogenetics of Donepezil and Memantine in Healthy Subjects
por: Ovejero-Benito, María C., et al.
Publicado: (2022)

Large Cryogenic Magnetostriction Induced by Hydrostatic Pressure in MnCo(0.92)Ni(0.08)Si Alloy
por: Hao, Xiaowen, et al.
Publicado: (2023)

Insulating phase at low temperature in ultrathin La(0.8)Sr(0.2)MnO(3) films
por: Feng, Yaqing, et al.
Publicado: (2016)

Memantine ameliorates motor impairments and pathologies in a mouse model of neuromyelitis optica spectrum disorders
por: Yick, Leung-Wah, et al.
Publicado: (2020)

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease
por: Huang, Xianfeng, et al.
Publicado: (2021)

Is memantine a potential therapeutic for Rett syndrome?
por: Bello, Olivia, et al.
Publicado: (2013)

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
por: Majláth, Zsófia, et al.
Publicado: (2016)

Crystal structure of memantine–carboxyborane
por: Ayudhya, Theppawut I., et al.
Publicado: (2019)

Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease
por: Marotta, Giambattista, et al.
Publicado: (2020)

Galantamine-memantine combination superior to donepezil-memantine combination in Alzheimer’s disease: critical dissection with an emphasis on kynurenic acid and mismatch negativity
por: Koola, Maju Mathew, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_67o2i7u1nh9qfakc804eg29v7l