Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions

Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related differentially expressed g...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Xiao, Sun, Shixiang, Zhang, Lei, Kim, Seungsoo, Tu, Zhidong, Montagna, Cristina, Maslov, Alexander Y., Suh, Yousin, Wang, Tao, Campisi, Judith, Vijg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208793/
https://www.ncbi.nlm.nih.gov/pubmed/34018656
http://dx.doi.org/10.1111/acel.13357
Descripción
Sumario:Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome‐wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.

Ejemplares similares