Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions

Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related differentially expressed g...

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Autores principales: Dong, Xiao, Sun, Shixiang, Zhang, Lei, Kim, Seungsoo, Tu, Zhidong, Montagna, Cristina, Maslov, Alexander Y., Suh, Yousin, Wang, Tao, Campisi, Judith, Vijg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208793/
https://www.ncbi.nlm.nih.gov/pubmed/34018656
http://dx.doi.org/10.1111/acel.13357
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author Dong, Xiao
Sun, Shixiang
Zhang, Lei
Kim, Seungsoo
Tu, Zhidong
Montagna, Cristina
Maslov, Alexander Y.
Suh, Yousin
Wang, Tao
Campisi, Judith
Vijg, Jan
author_facet Dong, Xiao
Sun, Shixiang
Zhang, Lei
Kim, Seungsoo
Tu, Zhidong
Montagna, Cristina
Maslov, Alexander Y.
Suh, Yousin
Wang, Tao
Campisi, Judith
Vijg, Jan
author_sort Dong, Xiao
collection PubMed
description Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome‐wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.
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spelling pubmed-82087932021-06-25 Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions Dong, Xiao Sun, Shixiang Zhang, Lei Kim, Seungsoo Tu, Zhidong Montagna, Cristina Maslov, Alexander Y. Suh, Yousin Wang, Tao Campisi, Judith Vijg, Jan Aging Cell Original Articles Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome‐wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging. John Wiley and Sons Inc. 2021-05-21 2021-06 /pmc/articles/PMC8208793/ /pubmed/34018656 http://dx.doi.org/10.1111/acel.13357 Text en © 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Dong, Xiao
Sun, Shixiang
Zhang, Lei
Kim, Seungsoo
Tu, Zhidong
Montagna, Cristina
Maslov, Alexander Y.
Suh, Yousin
Wang, Tao
Campisi, Judith
Vijg, Jan
Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
title Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
title_full Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
title_fullStr Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
title_full_unstemmed Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
title_short Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
title_sort age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208793/
https://www.ncbi.nlm.nih.gov/pubmed/34018656
http://dx.doi.org/10.1111/acel.13357
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