Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog

Decreasing the partition coefficient (LogP) by the introduction of a hydrophilic group is the conventional approach for improving the aqueous solubility of drug candidates, but is not always effective. Since melting point is related to aqueous solubility, we and other groups have developed alternati...

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Detalles Bibliográficos
Autores principales: Morimoto, Junki, Miyamoto, Kazunori, Ichikawa, Yuki, Uchiyama, Masanobu, Makishima, Makoto, Hashimoto, Yuichi, Ishikawa, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209153/
https://www.ncbi.nlm.nih.gov/pubmed/34135380
http://dx.doi.org/10.1038/s41598-021-92028-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209153/
https://www.ncbi.nlm.nih.gov/pubmed/34135380
http://dx.doi.org/10.1038/s41598-021-92028-y

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