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A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models
CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX). To enrich CRISPR/Cas9-edited cells, we improved a dual-reporter sy...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209181/ https://www.ncbi.nlm.nih.gov/pubmed/34135367 http://dx.doi.org/10.1038/s41598-021-91760-9 |