VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway

Clear cell renal cell carcinomas (ccRCC) reprogram carbon metabolism responses to hypoxia, thereby promoting utilization of glutamine. Recently, sirtuin 4 (SIRT4), a novel molecular has turned out to be related to alternating glutamine metabolism and modulating the tumor microenvironment. However, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Tong, Ying, Kai, Jinyan, Wang, Shuo, Yu, Yiwen, Xie, Suhong, Zheng, Hui, Wang, Yanchun, Liu, Yixuan, Zhu, Keyu, Guan, Xiaolin, Guo, Lin, Lu, Renquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209205/
https://www.ncbi.nlm.nih.gov/pubmed/34135317
http://dx.doi.org/10.1038/s41419-021-03901-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209205/
https://www.ncbi.nlm.nih.gov/pubmed/34135317
http://dx.doi.org/10.1038/s41419-021-03901-7

Ejemplares similares