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VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway

Clear cell renal cell carcinomas (ccRCC) reprogram carbon metabolism responses to hypoxia, thereby promoting utilization of glutamine. Recently, sirtuin 4 (SIRT4), a novel molecular has turned out to be related to alternating glutamine metabolism and modulating the tumor microenvironment. However, t...

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Detalles Bibliográficos
Autores principales:	Tong, Ying, Kai, Jinyan, Wang, Shuo, Yu, Yiwen, Xie, Suhong, Zheng, Hui, Wang, Yanchun, Liu, Yixuan, Zhu, Keyu, Guan, Xiaolin, Guo, Lin, Lu, Renquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209205/ https://www.ncbi.nlm.nih.gov/pubmed/34135317 http://dx.doi.org/10.1038/s41419-021-03901-7

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