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Unchecked nick ligation can promote localized genome re-replication
Single-stranded DNA breaks, or nicks, are amongst the most common forms of DNA damage in cells. They can be repaired by ligation; however, if a nick occurs just ahead of an approaching replisome, the outcome is a collapsed replication fork comprising a single-ended double-strand break and a ‘hybrid...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209288/ https://www.ncbi.nlm.nih.gov/pubmed/34102115 http://dx.doi.org/10.1016/j.cub.2021.03.043 |