Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes

Cardiac Troponin I (cTnI) is a subunit of the thin filament involved in regulation of heart contraction. Mutated cTnI accounts for most genetic mutations associated with restrictive cardiomyopathy (RCM). We previously found phosphodiesterase 4D (PDE4D) decreased in RCM mice with cTnIR193H mutation a...

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Detalles Bibliográficos
Autores principales: Zhao, Weian, Qian lu, Luo, Jing, Pan, Bo, Liu, Ling-Juan, Tian, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209310/
https://www.ncbi.nlm.nih.gov/pubmed/34179318
http://dx.doi.org/10.1016/j.gendis.2020.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209310/
https://www.ncbi.nlm.nih.gov/pubmed/34179318
http://dx.doi.org/10.1016/j.gendis.2020.01.004

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