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Cas9-targeted nanopore sequencing reveals epigenetic heterogeneity after de novo assembly of native full-length hepatitis B virus genomes
Hepatitis B virus (HBV) contains a 3.2 kb DNA genome and causes acute and chronic hepatitis. HBV infection is a global health problem, with 350 million chronically infected people at increased risk of developing liver disease and hepatocellular carcinoma (HCC). Methylation of HBV DNA in a CpG contex...
Autores principales: | Goldsmith, Chloe, Cohen, Damien, Dubois, Anaëlle, Martinez, Maria Guadalupe, Petitjean, Kilian, Corlu, Anne, Testoni, Barbara, Hernandez-Vargas, Hector, Chemin, Isabelle |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209722/ https://www.ncbi.nlm.nih.gov/pubmed/34003741 http://dx.doi.org/10.1099/mgen.0.000507 |
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