Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis

The aging liver is affected by several disorders, including steatosis, that can lead to a decline of liver functions. Here, we present evidence that the cdk4-C/EBPα-p300 axis is a critical regulator of age-associated disorders, including steatosis. We found that patients with non-alcoholic fatty liv...

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Detalles Bibliográficos
Autores principales: Nguyen, Phuong, Valanejad, Leila, Cast, Ashley, Wright, Mary, Garcia, Jose M., El-Serag, Hashem B., Karns, Rebekah, Timchenko, Nikolai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209958/
https://www.ncbi.nlm.nih.gov/pubmed/30089269
http://dx.doi.org/10.1016/j.celrep.2018.07.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209958/
https://www.ncbi.nlm.nih.gov/pubmed/30089269
http://dx.doi.org/10.1016/j.celrep.2018.07.014

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