CDK12: cellular functions and therapeutic potential of versatile player in cancer

Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain of RNA polymerase II and is needed for the optimal transcription elongation and translation of a subset of human protein-coding genes. The kinase has a pleiotropic effect on the maintenance of genome stability, and its inactivat...

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Detalles Bibliográficos
Autores principales: Pilarova, Kveta, Herudek, Jan, Blazek, Dalibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210036/
https://www.ncbi.nlm.nih.gov/pubmed/34316683
http://dx.doi.org/10.1093/narcan/zcaa003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210036/
https://www.ncbi.nlm.nih.gov/pubmed/34316683
http://dx.doi.org/10.1093/narcan/zcaa003

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