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CDK12: cellular functions and therapeutic potential of versatile player in cancer

Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain of RNA polymerase II and is needed for the optimal transcription elongation and translation of a subset of human protein-coding genes. The kinase has a pleiotropic effect on the maintenance of genome stability, and its inactivat...

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Detalles Bibliográficos
Autores principales:	Pilarova, Kveta, Herudek, Jan, Blazek, Dalibor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Survey and Summary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210036/ https://www.ncbi.nlm.nih.gov/pubmed/34316683 http://dx.doi.org/10.1093/narcan/zcaa003

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