Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses

Arming oncolytic adenoviruses with therapeutic transgenes is a well-established strategy for multimodal tumour attack. However, this strategy sometimes leads to unexpected attenuated viral replication and a loss of oncolytic effects, preventing these viruses from reaching the clinic. Previous work h...

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Detalles Bibliográficos
Autores principales: Núñez-Manchón, Estela, Farrera-Sal, Martí, Otero-Mateo, Marc, Castellano, Giancarlo, Moreno, Rafael, Medel, David, Alemany, Ramon, Villanueva, Eneko, Fillat, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid-Based Cancer Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210037/
https://www.ncbi.nlm.nih.gov/pubmed/34316705
http://dx.doi.org/10.1093/narcan/zcab015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210037/
https://www.ncbi.nlm.nih.gov/pubmed/34316705
http://dx.doi.org/10.1093/narcan/zcab015

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