Synthetic circular miR-21 RNA decoys enhance tumor suppressor expression and impair tumor growth in mice

Naturally occurring circular RNAs efficiently impair miRNA functions. Synthetic circular RNAs may thus serve as potent agents for miRNA inhibition. Their therapeutic effect critically relies on (i) the identification of optimal miRNA targets, (ii) the optimization of decoy structures and (iii) the d...

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Detalles Bibliográficos
Autores principales: Müller, Simon, Wedler, Alice, Breuer, Janina, Glaß, Markus, Bley, Nadine, Lederer, Marcell, Haase, Jacob, Misiak, Claudia, Fuchs, Tommy, Ottmann, Alina, Schmachtel, Tessa, Shalamova, Lyudmila, Ewe, Alexander, Aigner, Achim, Rossbach, Oliver, Hüttelmaier, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid-Based Cancer Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210135/
https://www.ncbi.nlm.nih.gov/pubmed/34316687
http://dx.doi.org/10.1093/narcan/zcaa014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210135/
https://www.ncbi.nlm.nih.gov/pubmed/34316687
http://dx.doi.org/10.1093/narcan/zcaa014

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