SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

The SWI/SNF chromatin remodeling complex regulates transcription through the control of chromatin structure and is increasingly thought to play an important role in human cancer. Lung adenocarcinoma (LADC) patients frequently harbor mutations in SMARCA4, a core component of this multisubunit complex...

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Detalles Bibliográficos
Autores principales: Kurashima, Kiminori, Kashiwagi, Hideto, Shimomura, Iwao, Suzuki, Ayako, Takeshita, Fumitaka, Mazevet, Marianne, Harata, Masahiko, Yamashita, Takayuki, Yamamoto, Yusuke, Kohno, Takashi, Shiotani, Bunsyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210217/
https://www.ncbi.nlm.nih.gov/pubmed/34316685
http://dx.doi.org/10.1093/narcan/zcaa005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210217/
https://www.ncbi.nlm.nih.gov/pubmed/34316685
http://dx.doi.org/10.1093/narcan/zcaa005

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