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TPR1, a novel rifampicin derivative, demonstrates efficacy alone and in combination with doxycycline against the NIAID Category A priority pathogen Francisella tularensis

BACKGROUND: Francisella tularensis is a highly virulent and contagious Gram-negative intracellular bacterium that causes the disease tularaemia in mammals and is classified as a Category A priority pathogen. METHODS: We utilized a systematic analysis of antibacterial potency, extent of dissemination...

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Detalles Bibliográficos
Autores principales: Cummings, Jason E, Slayden, Keaton W, Slayden, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210291/
https://www.ncbi.nlm.nih.gov/pubmed/34223120
http://dx.doi.org/10.1093/jacamr/dlab058