Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo

Excessive bone resorption by osteoclasts contributes significantly to osteoclast-related diseases such as periprosthetic osteolysis and osteoporosis. Osteolysis in a titanium particle-induced calvarial model and bone loss in an ovariectomized mice model occurred similarly to those in humans; thus, t...

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Detalles Bibliográficos
Autores principales: Xu, Qiang, Chen, Guiping, Xu, Huaen, Xia, Guoming, Zhu, Meisong, Zhan, Haibo, Zhang, Bin, Dai, Min, Fan, Hongxian, Liu, Xuqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210420/
https://www.ncbi.nlm.nih.gov/pubmed/34149427
http://dx.doi.org/10.3389/fphar.2021.682541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210420/
https://www.ncbi.nlm.nih.gov/pubmed/34149427
http://dx.doi.org/10.3389/fphar.2021.682541

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