Discovery and Optimization of Highly Potent and Selective AT(2)R Antagonists to Relieve Peripheral Neuropathic Pain

[Image: see text] The angiotensin II type 2 receptor (AT(2)R) has attracted much attention as a potential target for the relief of neuropathic pain, which represents an area of unmet clinical need. A series of 1,2,3,4-tetrahydroisoquinolines with a benzoxazole side-chain were discovered as potent AT...

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Detalles Bibliográficos
Autores principales: Guo, Yanghui, Huang, Xiangui, Liao, Weiwei, Meng, Lichen, Xu, Daiwang, Ye, Cheng, Chen, Lei, Hu, Taishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210434/
https://www.ncbi.nlm.nih.gov/pubmed/34151119
http://dx.doi.org/10.1021/acsomega.1c01866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210434/
https://www.ncbi.nlm.nih.gov/pubmed/34151119
http://dx.doi.org/10.1021/acsomega.1c01866

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