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Discovery and Optimization of Highly Potent and Selective AT(2)R Antagonists to Relieve Peripheral Neuropathic Pain
[Image: see text] The angiotensin II type 2 receptor (AT(2)R) has attracted much attention as a potential target for the relief of neuropathic pain, which represents an area of unmet clinical need. A series of 1,2,3,4-tetrahydroisoquinolines with a benzoxazole side-chain were discovered as potent AT...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210434/ https://www.ncbi.nlm.nih.gov/pubmed/34151119 http://dx.doi.org/10.1021/acsomega.1c01866 |