Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts

Chimeric antigen receptor T-cells (CAR T-cells) for the treatment of relapsing/refractory B-cell precursor acute lymphoblastic leukemia have led to exciting clinical results. However, CAR T-cell approaches revealed a potential risk of CD19-/CAR+ leukemic relapse due to inadvertent transduction of le...

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Detalles Bibliográficos
Autores principales: Quintarelli, Concetta, Guercio, Marika, Manni, Simona, Boffa, Iolanda, Sinibaldi, Matilde, Di Cecca, Stefano, Caruso, Simona, Abbaszadeh, Zeinab, Camera, Antonio, Cembrola, Biancamaria, Ciccone, Roselia, Orfao, Alberto, Martin-Martin, Lourdes, Gutierrez-Herrero, Sara, Herrero-Garcia, Maria, Cazzaniga, Gianni, Nunes, Vittorio, Songia, Simona, Marcatili, Paolo, Marin, Frederikke I, Ruella, Marco, Bertaina, Valentina, Vinti, Luciana, Del Bufalo, Francesca, Algeri, Mattia, Merli, Pietro, De Angelis, Biagio, Locatelli, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211055/
https://www.ncbi.nlm.nih.gov/pubmed/34135100
http://dx.doi.org/10.1136/jitc-2020-001514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211055/
https://www.ncbi.nlm.nih.gov/pubmed/34135100
http://dx.doi.org/10.1136/jitc-2020-001514

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