Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment

BACKGROUND: The temporal response to checkpoint blockade (CB) is incompletely understood. Here, we profiled the tumor infiltrating lymphocyte (TIL) landscape in response to combination checkpoint blockade at two distinct timepoints of solid tumor growth. METHODS: C57BL/6 mice bearing subcutaneous MC...

Descripción completa

Detalles Bibliográficos
Autores principales: Aoyama, Shota, Nakagawa, Ryosuke, Nemoto, Satoshi, Perez-Villarroel, Patricio, Mulé, James J, Mailloux, Adam William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211075/
https://www.ncbi.nlm.nih.gov/pubmed/34135102
http://dx.doi.org/10.1136/jitc-2020-002269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211075/
https://www.ncbi.nlm.nih.gov/pubmed/34135102
http://dx.doi.org/10.1136/jitc-2020-002269

Ejemplares similares