Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection

Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosome profiling to investigate holistically the transc...

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Detalles Bibliográficos
Autores principales: Echavarría-Consuegra, Liliana, Cook, Georgia M., Busnadiego, Idoia, Lefèvre, Charlotte, Keep, Sarah, Brown, Katherine, Doyle, Nicole, Dowgier, Giulia, Franaszek, Krzysztof, Moore, Nathan A., Siddell, Stuart G., Bickerton, Erica, Hale, Benjamin G., Firth, Andrew E., Brierley, Ian, Irigoyen, Nerea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211288/
https://www.ncbi.nlm.nih.gov/pubmed/34138976
http://dx.doi.org/10.1371/journal.ppat.1009644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211288/
https://www.ncbi.nlm.nih.gov/pubmed/34138976
http://dx.doi.org/10.1371/journal.ppat.1009644

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