The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice

The conserved CD94/NKG2A inhibitory receptor is expressed by nearly all human and ∼50% of mouse uterine natural killer (uNK) cells. Binding human HLA-E and mouse Qa-1, NKG2A drives NK cell education, a process of unknown physiological importance influenced by HLA-B alleles. Here, we show that NKG2A...

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Detalles Bibliográficos
Autores principales: Shreeve, Norman, Depierreux, Delphine, Hawkes, Delia, Traherne, James A., Sovio, Ulla, Huhn, Oisin, Jayaraman, Jyothi, Horowitz, Amir, Ghadially, Hormas, Perry, John R.B., Moffett, Ashley, Sled, John G., Sharkey, Andrew M., Colucci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211638/
https://www.ncbi.nlm.nih.gov/pubmed/33887202
http://dx.doi.org/10.1016/j.immuni.2021.03.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211638/
https://www.ncbi.nlm.nih.gov/pubmed/33887202
http://dx.doi.org/10.1016/j.immuni.2021.03.021

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