GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease. CD68-positive bone marrow (BM)-derived cells (BMDCs) accumulate in the pathological lesion in the SOD1(G93A) ALS mouse model after BM transplantation (BMT). Therefore, we investigated whether BMDCs can be applied as gen...

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Detalles Bibliográficos
Autores principales: Ohashi, Natsuko, Terashima, Tomoya, Katagi, Miwako, Nakae, Yuki, Okano, Junko, Suzuki, Yoshihisa, Kojima, Hideto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211665/
https://www.ncbi.nlm.nih.gov/pubmed/34140581
http://dx.doi.org/10.1038/s41598-021-92285-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211665/
https://www.ncbi.nlm.nih.gov/pubmed/34140581
http://dx.doi.org/10.1038/s41598-021-92285-x

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