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Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
The HIV-1 accessory proteins Vif, Vpu, and Nef can promote infection by overcoming the inhibitory effects of the host cell restriction factors APOBEC3G, Tetherin, and SERINC5, respectively. However, how the HIV-1 accessory protein Vpr enhances infection in macrophages but not in CD4(+) T cells remai...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211709/ https://www.ncbi.nlm.nih.gov/pubmed/34140527 http://dx.doi.org/10.1038/s41467-021-24087-8 |