Efficient precise in vivo base editing in adult dystrophic mice

Recent advances in base editing have created an exciting opportunity to precisely correct disease-causing mutations. However, the large size of base editors and their inherited off-target activities pose challenges for in vivo base editing. Moreover, the requirement of a protospacer adjacent motif (...

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Detalles Bibliográficos
Autores principales: Xu, Li, Zhang, Chen, Li, Haiwen, Wang, Peipei, Gao, Yandi, Mokadam, Nahush A., Ma, Jianjie, Arnold, W. David, Han, Renzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211797/
https://www.ncbi.nlm.nih.gov/pubmed/34140489
http://dx.doi.org/10.1038/s41467-021-23996-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211797/
https://www.ncbi.nlm.nih.gov/pubmed/34140489
http://dx.doi.org/10.1038/s41467-021-23996-y

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