Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway

BACKGROUND: Hashimoto’s thyroiditis (HT) is an autoimmune disease that features activation of thyroid antigen-specific helper T cells. HT patients have increased Th1 and Th17 T cell subsets. Glycolysis supports chronic activation of Th1 and Th17 T cells, but how this contributes to HT remains unknow...

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Detalles Bibliográficos
Autores principales: Zhao, Lei, Wu, Qiong, Wang, Xiaoli, Wang, Shiqi, Shi, Xiaoguang, Shan, Zhongyan, Teng, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211914/
https://www.ncbi.nlm.nih.gov/pubmed/34149615
http://dx.doi.org/10.3389/fendo.2021.659738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211914/
https://www.ncbi.nlm.nih.gov/pubmed/34149615
http://dx.doi.org/10.3389/fendo.2021.659738

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