Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats

OBJECTIVE: To investigate the role of the deubiquitinase ubiquitin C-terminal hydrolase L1 (UCHL1) in hypertension and retinopathy in the spontaneously hypertensive rat (SHR). METHODS: Wistar–Kyoto (WKY) rats and SHRs were administered the UCHL1 inhibitor LDN57444 (20 μg/kg/day) for 4 months. Pathol...

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Detalles Bibliográficos
Autores principales: Liu, Shasha, Wang, Chengfang, Lu, Jianmin, Dai, Guangzheng, Che, Huixin, He, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Prospective Clinical Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212382/
https://www.ncbi.nlm.nih.gov/pubmed/34130526
http://dx.doi.org/10.1177/03000605211020641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212382/
https://www.ncbi.nlm.nih.gov/pubmed/34130526
http://dx.doi.org/10.1177/03000605211020641

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