A phase 2 trial of gemcitabine and docetaxel in patients with metastatic colorectal adenocarcinoma with methylated checkpoint with forkhead and ring finger domain promoter and/or microsatellite instability phenotype

ABSTRACT: We previously reported CHFR methylation in a subset of colorectal cancer (CRC; ∼30%) with high concordance with microsatellite instability (MSI). We also showed that CHFR methylation predicted for sensitivity to docetaxel, whereas the MSI‐high phenotypes were sensitive to gemcitabine. We h...

Descripción completa

Detalles Bibliográficos
Autores principales: Baretti, Marina, Karunasena, Enusha, Zahurak, Marianna, Walker, Rosalind, Zhao, Yang, Pisanic, Thomas R., Wang, Tza‐Huei, Greten, Tim F., Duffy, Austin G., Gootjes, Elske, Meijer, Gerrit, Verheul, Henk M.W., Ahuja, Nita, Herman, James G., Azad, Nilofer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212722/
https://www.ncbi.nlm.nih.gov/pubmed/33811727
http://dx.doi.org/10.1111/cts.12960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212722/
https://www.ncbi.nlm.nih.gov/pubmed/33811727
http://dx.doi.org/10.1111/cts.12960

Ejemplares similares