PK11195 Protects From Cell Death Only When Applied During Reperfusion: Succinate-Mediated Mechanism of Action

Aim: Reperfusion after myocardial ischemia causes cellular injury, in part due to changes in mitochondrial Ca(2+) handling, oxidative stress, and myocyte energetics. We have previously shown that the 18-kDa translocator protein of the outer mitochondrial membrane (TSPO) can modulate Ca(2+) handling....

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Detalles Bibliográficos
Autores principales: Seidlmayer, Lea K., Hanson, Benjamin J., Thai, Phung N., Schaefer, Saul, Bers, Donald M., Dedkova, Elena N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212865/
https://www.ncbi.nlm.nih.gov/pubmed/34149440
http://dx.doi.org/10.3389/fphys.2021.628508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212865/
https://www.ncbi.nlm.nih.gov/pubmed/34149440
http://dx.doi.org/10.3389/fphys.2021.628508

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