Cargando…
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung
Mutations in LRRK2 are the most frequent cause of familial Parkinson’s disease (PD), with common LRRK2 non-coding variants also acting as risk factors for idiopathic PD. Currently, therapeutic agents targeting LRRK2 are undergoing advanced clinical trials in humans, however, it is important to under...
Autores principales: | Verma, Amrita, Ebanks, Kirsten, Fok, Chi-Yee, Lewis, Patrick A., Bettencourt, Conceicao, Bandopadhyay, Rina |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier/North-Holland Biomedical Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212912/ https://www.ncbi.nlm.nih.gov/pubmed/33915162 http://dx.doi.org/10.1016/j.brainres.2021.147503 |
Ejemplares similares
-
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2
por: Nazish, Iqra, et al.
Publicado: (2023) -
Vesicular Dysfunction and the Pathogenesis of Parkinson’s Disease: Clues From Genetic Studies
por: Ebanks, Kirsten, et al.
Publicado: (2020) -
Computational analysis of the LRRK2 interactome
por: Manzoni, Claudia, et al.
Publicado: (2015) -
Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit
por: Zhao, Yibo, et al.
Publicado: (2023) -
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases()
por: Mamais, Adamantios, et al.
Publicado: (2013)