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ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression

Opioids are perhaps the most effective analgesics in medicine. However, between 1999 and 2018, over 400,000 people in the United States died from opioid overdose. Excessive opioids make breathing lethally slow and shallow, a side-effect called opioid-induced respiratory depression. This doubled-edge...

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Detalles Bibliográficos
Autores principales: Bachmutsky, Iris, Wei, Xin Paul, Durand, Adelae, Yackle, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213404/
https://www.ncbi.nlm.nih.gov/pubmed/34002697
http://dx.doi.org/10.7554/eLife.62552