Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol

Merck KGaA observed slight differences in the dissolution of Concor(®) (bisoprolol) batches over the years. The purpose of this work was to assess the impact of in vitro dissolution on the simulated pharmacokinetics of bisoprolol using in vitro–in vivo relationship established with available in vitr...

Descripción completa

Detalles Bibliográficos
Autores principales: Macwan, Joyce S., Fraczkiewicz, Grace, Bertolino, Mauro, Krüger, Phillip, Peters, Sheila‐Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213417/
https://www.ncbi.nlm.nih.gov/pubmed/34080804
http://dx.doi.org/10.1002/psp4.12634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213417/
https://www.ncbi.nlm.nih.gov/pubmed/34080804
http://dx.doi.org/10.1002/psp4.12634

Ejemplares similares