TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-based mechanism elongating telomeres in a subset of human cancer cells. While the notion that spontaneous DNA damage at telomeres is required to initiate ALT, the molecular triggers of this physiological telomere instabi...

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Detalles Bibliográficos
Autores principales: Silva, Bruno, Arora, Rajika, Bione, Silvia, Azzalin, Claus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213692/
https://www.ncbi.nlm.nih.gov/pubmed/34145295
http://dx.doi.org/10.1038/s41467-021-24097-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213692/
https://www.ncbi.nlm.nih.gov/pubmed/34145295
http://dx.doi.org/10.1038/s41467-021-24097-6

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